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Nat Rev Nephrol 13 , 605628 (2017)

The specific functional logic is as follows: In addition to GPR activation, SCFAs (especially butyrate) cross the blood-brain barrier via monocarboxylate transporter 1 (MCT1) and inhibit HDAC1/2 in the hippocampus and prefrontal cortexbrain regions critical for mood regulation

No difference in serum levels of glutamate has been reported between children with autistic disorder and controls [69, 70], however, it was significantly higher in adults with autistic disorder [75], the level being positively correlated with social functioning as measured by the autism diagnostic interview (ADI-R) [103] which is commonly used to evaluate the core symptoms of autism which may shed light on the significantly higher level detected in mixed samples of children with autism spectrum disorders [86, 87]

Smaller meals, reduced fat intake, and slower eating patterns can help minimize nausea and fullness