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Moreover, the SELECT study showed that semaglutide significantly reduced the incidence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke (hazard ratio 0.80) (12)

This has been highlighted by the Australian Therapeutic Goods Administration (TGA), which has released a Medicines Safety Update with new warnings to be added to the product information of this class of drugs about risks during anaesthesia or deep sedation

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Animal studies show that peripheral GLP-1 agonism modulates dopamine release in the ventral striatum, dampens cocaine-seeking behavior, reduces nicotine self-administration, attenuates the locomotor response to amphetamine, and blunts stress-induced reinstatement of drug seeking across multiple paradigms