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Huang Y., Shen W., Su J., et al., Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects Against AmyloidInduced Neurotoxicity, Journal of Alzheimer's Disease 57 (2017): 885897

In contrast, the subjects of clinical trials are complex patient populations, particularly elderly individuals with comorbid sarcopenia, obesity, or multiple metabolic diseases, whose muscle metabolic foundation is more fragile [63]