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In the central nervous system (CNS), P300 and its homologous protein CBP participate in the physiological processes of various diseases by mediating histone and non-histone lactylation

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Led by scientists from the United States, Brazil, Iran, and Israel, the study highlights that while GLP-1 receptor agonists can be beneficial for individuals with hyperdopaminergia (elevated dopamine activity), they may have adverse effects on those with hypodopaminergia (reduced dopamine function)