surmount-1 trial tirzepatide non-diabetic obesity weight loss SURMOUNT-5: Bests Semaglutide in Head-to-Head Tirzepatide after intensive lifestyle intervention

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Approximately 1,500 patients with T2D and Early Treatment Diabetic Retinopathy Study (ETDRS) level of 1075 in both eyes and no ocular or intraocular treatment for diabetic retinopathy or diabetic macular edema in the 6 months prior to screening will receive once-weekly subcutaneous semaglutide 1.0 mg or placebo for up to 5 years, with the primary endpoint of progression of 3 steps or more in ETDRS level