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Both semaglutide and tirzepatide GLP-1s have the GLP-1 receptor but tirzepatide has the additional receptor of GIP(Glucose-Dependent Insulinotropic Polypeptide)that helps with lowering inflammation, improving glucose control and enhancing bran signaling

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648 Preclinical studies have shown that MSC transplantation improves nerve function and reduces neuropathic pain in diabetic animal models 649

Moreover, TUNEL staining revealed no significant differences between normoglycemic mice and hyperglycemic mice in the percentage of apoptotic cells in grafts, excluding the possibility that increased apoptosis was responsible for the reduction in cells (Supplementary information, Fig