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In vivo animal studies confirm these findings, showing that IGF-1 treatment accelerates functional recovery from Achilles tendon injury, improves tendon mechanical properties, and enhances collagen organization and composition in healing ligaments
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Patient education should emphasize the limited evidence base, experimental nature of treatment, and importance of ongoing monitoring
The second assessment performed by abstracts analysis, excluded studies in a language other than English, studies with lack of full text, reviews, case reports, animal studies and in-vitro studies
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