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doi: 10.7150/ijms.8.192
Furthermore, the endogenous peptide Agouti-related peptide (AgRP), which is an inverse agonist on MC4R and a competitive antagonist or ERK-biased agonist on MC3R, is known to increase food intake and body weight (30, 31)
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Therefore, when assessing the health risks of MPs, it is essential to consider the combined effects of an individuals initial microbiota state, dietary structure, genetic susceptibility, and co-exposure to environmental factors (Fig
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