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For researchers specifically interested in hepatic fat metabolism, the glucagon component distinguishes both survodutide and retatrutide from tirzepatide

These lipidation and amino acid substitutions solve two fundamental problems with native human amylin: its extremely short plasma half-life (measured in minutes) and its well-documented tendency toward amyloid fibril formation

The present study used the UK CPRD GOLD and Aurum databases, which routinely collect linkable but de-identified longitudinal data on demographics, medical records (coded using the Read codes or SNOMED-CT classification), clinical measures, and prescriptions from primary care practices [27, 28]

The experiment included detailed clinical, morphological, and histological assessments to determine the degree of joint degeneration and recovery following different intra-articular treatments [1]