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Because it degrades in blood in a pathway involving amino-peptidases, it may not be suitable for people who take medications that inhibit or are metabolized by peptidases (e.g., captopril, a treatment for hypertension).4 Also, based on what we know about other therapeutic peptides, we would say DSIP is contraindicated for women who are pregnant or breastfeeding as well as people with a personal history of cancer

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That structural feature is significant: proline residues resist proteolytic cleavage, making the peptide unusually stable in gastric conditions relative to most short peptides [1]

Any assertion to the contrary is not supported by evidence It IS fair to say that there is no clear evidence of harm in a relatively data free zone in humans, and that there is a plausible argument for benefit based upon in vitro and animal studies as well as mechanism of action - particularly with BPC