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People need to know from the start that these are prescribed as long-term medications for their effect on body weight, glucose levels, and potentially cardiovascular protection, Pratley says, adding that people dont stop antihypertensives or statins because they achieve or reach normal blood pressure or LDL cholesterol levels, respectively

Animal reproduction studies showed fetal harm at high doses, and inadequate human pregnancy data exist

As oral GLP-1 therapies move closer to commercialization, the importance of robust chemical manufacturing, high-quality intermediates, and process reliability will continue to grow

doi: 10.1016/j.cgh.2021.06.049 85 DesaiASehgalPKhataniarHLewisJDFarrayeFALichtensteinGRet al