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Taken together, these results suggest that the proposed mechanism involving A2AR signaling is dependent largely on gpx4 rather than other isoforms of GPXs in activated CD8 + T cells, while the potential contribution of other antioxidant enzymes requires further investigation

To a large extent, this tolerance development can be compensated for by gradually titrating the medication dose upwards, usually by adding a second dose in the early afternoon to provide reasonable all-day appetite control

Santini MT, et al