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The ratio of urinary carnitine/acylcarnitine excretion of the patients and healthy controls could have helped us to understand better the altered carnitine-acylcarnitine homeostasis in these late-diagnosed congenital hypothyroid patients under treatment

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Because of the broad scope required to synthesize Meldonium's historical context, pharmacological mechanisms, and varying international regulatory statuses, it does not employ formal systematic methodologies, such as a PRISMA flow diagram, strict inclusion/exclusion criteria, or standardized risk-of-bias assessment tools