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Stacking does not multiply the regulatory or safety concerns of either compound but does compound the research-only status of both - neither has FDA or EMA approval, and TB-500 specifically is on the WADA Prohibited List
Protocol details for specific injury types are available at Protocols
The metabolism and elimination of NAD+ (and its by-products) could be altered in advanced hepatic or renal dysfunction, and high-dose NAD+ might theoretically affect cardiovascular dynamics, so practitioners generally avoid or closely supervise NAD+ use in such settings
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