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Although structurally and functionally unique, this compound has poor pharmacokinetic properties due to its electrophilic nature that preclude potential clinical development 33

What GLP1 drugs are and why they work Glucagonlike peptide1 receptor agonists (GLP1 RAs) are medications that mimic the gut hormone GLP1, helping lower blood sugar and reduce appetite by enhancing glucosedependent insulin secretion and suppressing glucagon

Studies from the STEP clinical trial programme demonstrate that continuous treatment with semaglutide produces superior weight loss compared to interrupted therapy

Alternatively, participants could also be enrolled if they were aged 60 years or older and had cardiovascular risk factors