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When NNMT activity is dialed down, it allows for increased levels of nicotinamide adenine dinucleotide (NAD+), a coenzyme absolutely critical for countless metabolic processes, including energy production and cellular repair
These changes were correlated with altered activities of reactive oxygen species (ROS) and lipid biosynthesis-related enzymes, highlighting the pivotal role of MT in lipid accumulation (Li et al., 2017)
