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In SUSTAIN 3, SUSTAIN 7 and SUSTAIN 10, the GLP-1RAs semaglutide reduced HbA1c by up to 1.8%, achieved the glycemic control target of HbA1c in 80% of the intervention group, and reduced BW by up to 6.5 kg, outcomes which were superior to liraglutide, exenatide and dulaglutide [28-30]

Tryptic peptides were then concentrated and desalted using a Millipore C18 Zip Tip (Millipore)

Overall, these findings emphasize the importance of using multiple in silico tools to assess the pathogenicity of uncharacterized variants and while also highlighting the need for experimental validation to confirm their roles in disease

HOW TO RECONSTITUTE: Dilute the content of each vial in 8 ml of deionized water or Sodium Chloride