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As expected, the proportion of the GSH-low population significantly increased in SDSCs from older donors, compared with SDSCs from young donors (Supplementary Fig

After washing with PBS, the sections were coverslipped

doi: 10.1016/j.bbadis.2024.167301 119 AttaAAIbrahimWWMohamedAFAbdelkaderNF

Several lines of evidence indicated that SIRT3 deacetylates long-chain acyl-CoA dehydrogenase (LCAD), a critical enzyme for long-chain FA degradation, and carnitine palmitoyltransferase 2 (CPT2), a key enzyme for FA transfer, to enhance FAO [28,29,30,31]