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These pathways play a crucial role in its wide-ranging therapeutic effects, extending the benefits of GLP-1RAs beyond metabolic diseases

retatrutide research uk Gastrointestinal Effects (Most Common) Across trials, the most frequently reported adverse effects have been gastrointestinal (GI), typically: Nausea Diarrhoea Vomiting Constipation (reported in some participants) These effects are: Dose-dependent (more common at higher doses) Usually mild to moderate Often most noticeable during dose escalation phases This is consistent with what is already known about GLP-1 class compounds, where GI tolerability often improves over time and can be influenced by dose titration strategy

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