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Biotech consulting firm Iqvia reported that in 2023, the global weight loss drug market reached $24 billion, and predicted that number could reach $131 billion by 2028

10.1159/000508639 47 IsakaY.KimuraT.TakabatakeY

In addition, local hypoxic, acidic, and low-glucose environments further augment energy metabolism reprogramming in tumor cells, which not only upregulates antiapoptotic proteins, including protein kinase B (Akt) and hexokinase 2 (HK2) but also inhibits the proliferation of T lymphocytes, facilitating tumor cell immune escape [198]

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