glp-1 weight loss research The Blueprint: The Breakthrough Approach to Reduce Cravings, Eat Healthy, and Make This the Last Diet You'll Ever Need: PIERCE, LAUREN: 9781069730435 Books Key Facts GPs Should Know

The beneficial effect of TZT in T2DM and obesity is related to direct activation of GIP and GLP-1 receptors with subsequent improvement of insulin sensitivity and reduction of body weight

J Clin Endocrinol Metab 86:38533860 Lugari R, Dei Cas A, Ugolotti D et al (2002) Evidence for early impairment of glucagon-like peptide 1-induced insulin secretion in human type 2 (non insulin-dependent) diabetes

GLP-1 microdosing generally involves doses lower than those outlined in standard prescribing guidelines, which makes it an off-label use

Overall, our study highlights the importance of a broad approach to the evaluation of GLP-1RA pharmacology