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STEP 1 (semaglutide 2.4 mg, 68 weeks): Discontinuation due to GI AEs: 4.3% (vs 0.7% placebo) Key characteristics: GI events are most common during dose escalation and generally diminish over time Severe GI events occur in approximately 4% of patients The 16-week dose escalation schedule (0.25 mg to 2.4 mg) was designed to minimize GI impact Tirzepatide (Zepbound/Mounjaro)# Tirzepatide adds GIP receptor agonism to GLP-1 activity

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Hormonal imbalances like hypothyroidism, low testosterone, or menopause can slow metabolism and make weight loss more difficult