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Approved advanced therapies now include anti-tumor necrosis factor alpha (anti-TNF-) agents, anti-integrins, cytokine inhibitors targeting IL-12/23 and IL-23, Janus kinase (JAK) inhibitors, and sphingosine-1-phosphate receptor (S1PR) modulators

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Factors that accelerate weight loss include: High baseline insulin levels Significant visceral fat Pre-diabetes or metabolic syndrome Strong response to appetite suppression Factors that slow progress include: Perimenopause or menopause Low testosterone in men Thyroid dysfunction Chronic stress and poor sleep This is why medical monitoring and lab work matter

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