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This effect could mediate the clearance of ROS and inhibit NLRP3 activation (253)

The critical implication of these findings is that OA should be reconceptualized, in a significant subset of patients, as a systemic metabolic disorder rather than a purely localized joint disease

Type 2 diabetes In a separate study involving 281 adults with type 2 diabetes, the results published in the Lancet in June 2023 showed that individuals receiving the highest dose of retatrutide achieved a weight loss of approximately 17% of their body weight after nine months of treatment