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In addition, if lycopene and alpha-tocopherol have similar antioxidant functions (fat-soluble antioxidants), lycopenes potential antioxidant action is redundant to alpha-tocopherols antioxidant function and thus, also less likely to be a meaningful antioxidant

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Another rat study found that acute restraint stress can upregulate TLR4 gene expression in the frontal cortex by inducing gut microbiota translocation, while intervention with antibiotics or the TLR4 specific inhibitor TAK-242 effectively suppresses this process and reduces the accumulation of inflammatory and oxidative/nitrosative mediators (163)

Sulhan et al., 2020), leading to a sharp increase in intracranial pressure and eventually cerebral hernia (Winkler et al., 2016)