fda not allowing compounded semaglutide alerts health care providers, compounders and patients of dosing errors associated with injectable products Compounded Semaglutide & Tirzepatide 2025:

Large employers with self-funded insurance may handle these costs better

Clinical trials of brand-name semaglutide showed an average of 15% weight lossthese studies inform how the active ingredient is understood, but compounded semaglutide has not been independently studied for safety or efficacy

The national unadjusted payment rate for most APCs contained in Addendum A to this final rule with comment period (which is available on the CMS website at and for most HCPCS codes to which separate payment under the OPPS has been assigned in Addendum B to this final rule with comment period (which is available on the CMS website, see link above) is calculated by multiplying the final CY 2026 scaled weight for the APC by the CY 2026 conversion factor

NEJM, 2016