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doi: 10.1124/jpet.112.199497

Oral GLP-1s work similarly to injectables by reducing appetite, slowing down digestion, and improving blood sugar control

Salter JM

The reduction in steatosis in the GLP-1R agonist-treated group was accompanied by suppressed expression of hepatic genes for de novo lipogenesis ( Acc1 , Srebp1c and Fasn ), for reactive oxygen stress ( Nrf2 , Nox2 ) and inflammation ( Mpo , Il-6 , Il-12 ) (Fig