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The FDA prescribing information explicitly warns against taking vitamin A supplements alongside isotretinoin because of the risk of additive hypervitaminosis A toxicity, which can produce symptoms including pseudotumor cerebri (raised intracranial pressure), hepatotoxicity, and bone changes [1]

This method can present challenges when working with subjects that may have a fear of needles or lack experience with injections

In men, excess prolactin can reduce testosterone, causing decreased sex drive (libido), enlarged breasts (gynecomastia), erectile dysfunction, decreased body and facial hair

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