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Its versatility in detection modes is enhanced by advancements in backpressure regulator, injector, and column technology in new-generation instruments (Antonelli et al., 2022), enabling its combination with open cell detectors in MS (Le Faouder et al., 2021) and evaporative light scattering detectors (ELSD) (Lipka et al., 2019) for broader applications (Gros et al., 2021)