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In T1D, GLP-1s cannot replace insulin, but they may help: Reduce total daily insulin dose Improve post-meal glucose control Support weight loss in people with T1D and obesity However, this off-label use requires cautious monitoring, given the potential for hypoglycemia, DKA, and nutritional issues

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

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Inflammatory Bowel Diseases