As we age, levels of both NAD+ and glutathione decline, leading to reduced cellular efficiency and increased vulnerability to damage (Braidy et al., 2019)
A potential benefit of L-carnitine in these patients is based on the fact that it can (i) increase the oxidation of long-chain fatty acids which accumulation may contribute to insulin resistance in skeletal muscle, and (ii) enhance glucose utilization by reducing acyl-CoA concentration within the mitochondrial matrix (see Biological Activities) (42)
Pompella A, Visvikis A, Paolicchi A, De Tata V, Casini AF: The changing faces of glutathione, a cellular protagonist
Schnemann H, Broek J, Guyatt G, Oxman A GRADE handbook for grading quality of evidence and strength of recommendations