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Glucagon-like peptide-1 (GLP-1) receptor agonist and dual agonist therapies are FDA-approved for the treatment of obesity, weight management, type 2 diabetes mellitus and cardiovascular mortality reduction

Interestingly, agmatine, a metabolite produced by the gut bacterium Bacteroides vulgatus was shown to impair ovarian function by inhibiting GLP-1 secretion through activation of the farnesoid X receptor (FXR) (Yun et al., 2024)

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While the onset of fatigue may be challenging, its temporary nature offers reassurance to those considering or currently using Ozempic (semaglutide), Wegovy (semaglutide), or compounded semaglutide for their wellness goals