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In research models, this mechanism has been studied in the context of photoprotection in UV-sensitive conditions particularly erythropoietic protoporphyria (EPP), where clinical development of afamelanotide as a subcutaneous implant has resulted in regulatory approval in Europe and the United States

SAG S-acetyl-glutathione SAG S-acetyl-glutathione a delayed release delivery system designed to protect the molecule from degradation by gastric acids in the stomach and carry the SAG to the small intestine where it can be readily taken up intact by chylomicrons in the gut