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doi: 10.1007/s11060018-030711 47 KielFWStarrLBHansenJL

Under this hypoxic and high-fat dietary environment, adipose tissue exhibits significant immune cell infiltration (macrophages, T cells) accompanied by characteristic phenotypic shifts ( Local hypoxia during adipocyte hypertrophy also induces endoplasmic reticulum stress (ERS) ( 4.3.2 Cytokine-mediated ROS generation and OS Inflammatory cytokines promote ROS production through multiple pathways ( ROS activate the NLRP3 inflammasome ( 4.4 Obesity-induced gut microbiota dysbiosis and OS Through extensive studies, it has been demonstrated that obesity markedly changes the composition of microbiota ( The gut microbiota generates various reactive metabolites ( 2 O 2 ) and superoxide anions (O 2 - ), which directly modulate intestinal redox homeostasis

One of those places is the endothelial cells lining blood vessels that supply white adipose tissue

Gut microbiota induces mammary gland sIgA production to alleviate S