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Downstream saturation / spare receptor full physiological response often achieved well below full occupancy because the cells downstream signaling pathway has its own ceiling

The anti-adipogenic effect of PGF2 is mediated through prostaglandin F receptor-mediated elevation in intracellular calcium and DNA synthesis [168] and activation of MAPK, causing reduction in PPAR phosphorylation [169]

This was also observed in a second study (18/23 hospitalizations of immunized children, with two deaths, compared with 1/21 control cases) 16 and in two smaller studies 17,26

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