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This myth propagated in the 2000s, based on the factual information that eating and digesting food burns caloriesprotein in particular has a high thermic effect. Hence, if you ate 100 grams of protein in 10-gram increments, rather than two 50-gram doses, youd theoretically kindle the metabolic flame more often

While existing models continue to guide mechanistic research and therapeutic testing, further development of models that more closely align with human pathophysiology is crucial to improve translational validity (295, 303, 304)

doi: 10.1111/j.1749-6632.1998.tb08310.x

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