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Therefore, further investigation to identify which epigenetic factors, TFs or inflammatory mediators are directly responsible for establishing and maintaining these specific epigenetic memories in vivo would provide deeper mechanistic insights and shed light on potential therapeutic targets to prevent rUTIs and/or reverse the epigenetic imprinting that leads to increased susceptibility to recurrent disease

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FACLM investigates the 16 factors proposed to account for these findings, including additives, industrial contaminants, and packaging chemicals