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How This Works IGF-1 DES is a naturally-shortened variant of IGF-1: removing the N-terminal Gly-Pro-Glu tripeptide (and specifically the glutamate at position 3) greatly weakens its affinity for the IGF-binding proteins that normally sequester circulating IGF-1 [1]

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[113] Drug addiction and psychostimulants [edit] Cocaine, substituted amphetamines (including methamphetamine), Adderall, methylphenidate (marketed as Ritalin or Concerta), and other psychostimulants exert their effects primarily or partly by increasing dopamine levels in the brain by a variety of mechanisms

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