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Targeting ferroptosis: new perspectives of Chinese herbal medicine in the treatment of diabetes and its complications

In certain embodiments, any controlled release otic formulation described herein increases the exposure of a therapeutic agent and increases the length of time that the concentration of a therapeutic agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80% or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition

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In the duodenum and the small intestine, glibenclamide was released more efficiently and fast than metformin and sitagliptin, which had higher pK a values than glibenclamide, i.e., the metformin and sitagliptin were released more quickly and efficiently in pH 1.2 and pH 5.8