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It can be concluded that the dopaminergic deficit is efficiently compensated for a long period of time, at least 10 years or longer, during the normal or near-normal motor activity (silent/prodromal motor period) before clinical symptoms are sufficient for diagnosis (manifested period) [41]

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"The FDA approval of Wegovy pill -- the first oral GLP-1 for adults with obesity and overweight with weight-related medical problems -- has the potential to impact millions of Americans," Dave Moore, executive vice president of Novo Nordisk Inc.'s U.S