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Further evidence of NRF2s beneficial effects on ALS pathology were reported by clinical studies, which have shown that pharmacological activation of NRF2 improved the disease progression of ALS patients and reduced oxidative stress (Ahmadi et al., 2018

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Individuals with advanced alcoholism frequently present with clinical liver disease while reporting low perceived intoxication levels, precisely because neuroadaptive tolerance has altered CNS GABA-ergic and noradrenergic baseline signaling