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CD8 + T lymphocytes can upregulate perforin expression and increase MMP activity, resulting in the airway and lung tissue destruction, as well as chemotactic activation of inflammatory cells through secretion of cytokines such as interferon, IL-12, TNF- and chemokines, exacerbating the inflammatory response

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Additional evidence comes from a randomized controlled trial by Naing et al., which tested a structured insulin tapering protocol in patients with poorly controlled T2DM on multiple daily insulin injections

In a study performed on rabbits, in which their diet was enriched with carotenoids, serum levels of IgA, IgG, and IgM was elevated showing amelioration in their humoral immunity [27]