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Specifically, GLP-1s appear to dampen activity in reward-related regions like the nucleus accumbens, which plays a key role in cravings, dopamine release, and conditioned food responses

Twenty-four single-housed male DIO C57BL/6J mice at 47 weeks of age were divided into three groups based on body weight (i = 8 per group) as follows: Group 1 : Ad libitum access to a chow diet and high-fat diet for the duration of the experiment, and were treated at day 0 with a single intraperitoneal injection of isotonic saline

10.1136/jnnp-2019-322366 9 ChenT

Some individuals carry genetic variants associated with reduced glutathione recycling efficiency or lower basal antioxidant capacity