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Phase 3 trials include a 4mg maintenance arm specifically because some individuals achieve excellent results at lower doses

Semaglutide was dosed for the full period, while antibody dosing with the -MSTN and -ActA antibodies was started in Week 2 as an add-on to semaglutide and dosed through Week 12 (and was presumed to have more durable actions due to the extended half-life of the antibodies)

In the event of overdose, appropriate supportive treatment should be initiated according to the patients clinical signs and symptoms

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