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Large-scale research data, including pooled data from three randomized double-blind placebo-controlled cardiovascular outcome trials, and a nationwide Danish registry-based cohort in over 120,000 patients, suggests GLP-1s reduce the incidence of dementia, especially in patients with type 2 diabetes [19]

GLP-1 Agonists: Treatment Failure Does Not Preclude Prevention The November 2025 announcement from Novo Nordisk that oral semaglutide failed to slow Alzheimers progression in the EVOKE and EVOKE+ trials was widely reported as a setback

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