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Six participants cannot define a treatment effect A crossover design can be useful for exploratory research, but a study involving six people cannot establish uncommon risks, long-term effectiveness or suitability for people with different health conditions

Acta Neuropathol 132(2):277288 Zhu X, Shen K, Bai Y et al (2016) NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy [J]

Guo X, Lei M, Zhao J, Wu M, Ren Z, Yang X, Ouyang C, Liu X, Liu C, Chen Q

NoGLP-1 injections use thinner 31-gauge needles compared to standard insulin needles, which means less skin resistance and reduced pain during insertion