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For a comparison of those two, see our semaglutide vs tirzepatide breakdown

The magnitude of HbA1c reduction, rather than the medication itself, appeared to be the critical factor

Lyzenga-Dean highlights several drawbacks: "These drugs are expensive and rarely covered by insurance for folks who don't meet strict criteria, usually advanced diabetes." Additionally, these medications often require lifelong use to maintain results and can cause serious digestive side effects