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157 A partial explanation for the failure of the KD as a monotherapy in the ERGO trial could be based on the fact that there was no significant drop in blood glucose or HbA1c levels, and only part of the patients reached stable ketosis

Clinical studies have demonstrated exercise-induced increases in autophagy markers in human skeletal muscle, 164 while a randomized controlled trial in MASLD patients showed that intermittent fasting combined with aerobic exercise significantly reduced hepatic steatosis, body weight, and fat mass while improving insulin sensitivity

This is particularly beneficial for individuals with poor absorption, dietary restrictions, or higher metabolic needs

Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats