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238 Despite these gains, it has also been suggested that whereas conjugation shields targeting peptides from proteolysis to some extent, altering the peptide sequence to increase protease resistance can significantly increase homing and transport efficiency

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In line with the effects of selenium metabolism and selenoproteins in chondrogenic progenitor cells observed in vitro, deficient uptake of selenium severely affected chondrogenic differentiation of mesenchymal lineage cells and thus endochondral ossification in mice 64

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