Tissue Collection Mouse ileum was collected from female C57BL/6NTac mice (approximately 25 g body weight), and specimens from human terminal ileum were taken during colonoscopy as previously detailed ( Immunohistochemsitry Specimens of human and mouse ileum were fixed in 4% paraformaldehyde and embedded in paraffin
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A 2025 retrospective cohort of 125,474 adults initiating GLP-1 receptor agonists found that 46.5% of patients with type 2 diabetes and 64.8% without type 2 diabetes discontinued therapy within one year
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